A lemur in a tree

Multiple bursts of speciation in Madagascar’s endangered lemurs

Kathryn Everson and colleagues explore lemur evolution using a phylogenomic dataset with broad taxonomic sampling, revealing patterns of speciation, extinction, and gene flow.

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  • Z-DNA forms at highly active genes, but its function is unclear. Here, the authors show that MYC recruits FACT to promote Z-DNA formation within nucleosomes, enabling RNA Polymerase II loading and enhancing transcription, revealing a mechanistic role for Z-DNA in MYC-driven regulation.

    • Xinyi Wan
    • Haonan Fan
    • Dong Fang
    ArticleOpen Access
  • In this study, the authors use a combination of experimental and modeling approaches to show that a human gut bacterial community can exist in different states under the same conditions. The mechanism behind these alternative states is likely based on metabolic change in response to nutrient depletion.

    • Daniel Rios Garza
    • Bin Liu
    • Karoline Faust
    ArticleOpen Access
  • Homologous recombination is essential for DNA repair. Here, the authors present cryo-EM structures capturing five distinct intermediates of the RAD51 filament during strand exchange. These findings suggest a spatially coordinated, stepwise mechanism where the NTD guides DNA bending, while the L2 loop and S2 sites promote strand separation and product stabilization.

    • Shih-Chi Luo
    • Cheng-Han Yang
    • Meng-Chiao Ho
    ArticleOpen Access

Subjects within Biological sciences

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  • Aircraft contrails are not just streaks in clear blue skies - they represent a significant source of warming from the aviation sector. Two new studies reveal that their climate impact is more complex than previously thought, as many contrails may form within existing cirrus clouds – a factor often overlooked in past assessments. Drawing on aircraft, satellite and meteorological data, Petzold et al. and Seelig et al. provide fresh insights into the occurrence frequency and the radiative properties of these often “hidden” contrails.

    • Ziming Wang
    • Christiane Voigt
    CommentOpen Access
  • The performance of p-type transistors based on 2D semiconductors has not yet reached the level required for the realization of competitive complementary metal-oxide-semiconductor (CMOS) circuits. In this Comment, the authors discuss the recent developments, current challenges, and future outlook of 2D p-type transistors.

    • Jianfeng Jiang
    • Xudong Zheng
    • Lian-Mao Peng
    CommentOpen Access
  • Previous research has sought to determine the underlying mechanisms that govern the development of Alcohol Use Disorder (AUD). In a recent study by Ehinger et al., excessive alcohol consumption utilizes mTORC1’s under characterized role in repressing mRNA translation through the upregulation of microRNAs, specifically in a D1-circuit-specific manner, resulting in repression of glycolysis in the brain’s reward pathway.

    • Colin J. McArdle
    • Kimberly F. Raab-Graham
    CommentOpen Access
  • The European Centre for Medium-Range Weather Forecasts (ECMWF) is celebrating its 50th anniversary this year. In celebration of this occasion, we are talking with Dr. Florence Rabier, Director-General of the ECMWF, about what has been achieved over the last five decades and what opportunities and challenges lie ahead in the field of weather prediction.

    Q&AOpen Access
  • Portable genome sequencers are revolutionizing genomic research. However, their reliance on external systems introduces new vulnerabilities that threaten the security of these sequencers. By employing zero-trust principles throughout the sequencing workflow, we can enhance the security of portable sequencing technology.

    • Carson Stillman
    • Jonathan E. Bravo
    • Sara Rampazzi
    CommentOpen Access
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