Scholarship @ UWindsor

Scholarship @ UWindsor is the institutional repository of the University of Windsor (UWindsor), showcasing and preserving the UWindsor community’s scholarly outputs, as well as items from the Leddy Library’s Archives & Special Collections. Its mission is to disseminate and preserve knowledge created or housed at the University of Windsor.

Contact scholarship@uwindsor.ca for more information.

Communities in Scholarship @ UWindsor

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Conferences and Conference Proceedings 3167
Papers, presentations and abstracts of conferences held at the University of Windsor, in person and virtually.
Digitized Local Collections 1552
Digitized local items from the collections of the Leddy Library, University of Windsor, and community partners.
Faculties, Departments and Research Units 3391
Open Access Faculty publications, reports and working papers from academic departments at the University of Windsor.
Theses, Dissertations, and Major Papers 9578
Formal graduate original research from the University of Windsor's Masters and Doctoral programs.

Recent Submissions

Access status: Open Access ,
Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress
(Springer Science and Business Media LLC, 2017-10-01) Bolnick, Alan; Awonuga, Awoniyi O; Yang, Yu; Abdulhasan, Mohammed; Xie, Yufen; Zhou, Sichang; Puscheck, Elizabeth E.; Rappolee, Daniel A.
This review is a response to the Fellows Forum on testing 2% oxygen for best culture of human blastocysts (J Ass Reprod Gen 34:303–8, 1; J Ass Reprod Gen 34:309–14, 2) prior to embryo transfer. It is a general analysis in support of the position that an understanding of stem cell physiology and responses to oxygen are necessary for optimization of blastocyst culture in IVF and to enhance reproductive success in fertile women.
Access status: Open Access ,
Sub-types of nonbelieved memories reveal differential outcomes of challenges to memories
(Informa UK Limited, 2017-08-09) Scoboria, Alan; Nash, Robert A.; Mazzoni, Giuliana
Nonbelieved memories (NBMs) highlight the independence between distinct metamemorial judgements that contribute to the experience of remembering. Initial definitions of NBMs portrayed them as involving the withdrawal of belief in occurrence despite sustained recollection. While people rate belief for their NBMs as weaker than recollection, the average difference is too small to support the idea that autobiographical belief is completely withdrawn in all cases. Furthermore, autobiographical belief and recollection ratings vary considerably across NBMs. In two studies, we reanalysed data from prior studies to examine whether NBM reports reflect a single category or multiple sub-categories using cluster analytic methods. In Study 1, we identified three sub-types of NBMs. In Study 2 we incorporated the concept of belief in accuracy, and found that two of the clusters from Study 1 split into two clusters apiece. All clusters were characterised by higher recollection than belief in occurrence ratings, and clusters were differentiated by the degree of difference between these variables. In both studies the clusters were discriminated by a number of memory characteristic ratings and by reasons reported as leading to the alteration of belief. Implications for understanding the remembering of past events and predicting the creation of NBMs are discussed.
Access status: Open Access ,
Psychological and behavioral moderators of the relationship between trauma severity and HIV transmission risk behavior among MSM with a history of childhood sexual abuse
(Springer Science and Business Media LLC, 2017-10-01) Batchelder, Abigail W.; Ehlinger, Peter P.; Boroughs, Michael S.; Shipherd, Jillian C.; Safren, Steven A.; Ironson, Gail H.; O’Cleirigh, Conall
Childhood sexual abuse (CSA) is associated with post-traumatic stress disorder (PTSD), which can be associated with condomless sex among men who have sex with men (MSM). However, the impact of moderating factors on the relationship between PTSD symptom severity and condomless sex is poorly understood. We examined whether PTSD symptom severity was associated with condomless sex among MSM with CSA histories, and whether substance dependence, self-esteem, and distress tolerance moderated that relationship (n = 288). Notably, no direct relationship between PTSD symptom severity and condomless sex was found. Adjusted models indicated that condomless sex was differentially impacted by PTSD symptom severity among those without substance dependence (ΔR2 = 0.03, p = 0.034) and, counterintuitively, those with high self-esteem (ΔR2 = 0.07, p = 0.005). PTSD symptom severity was associated with condomless sex across levels of distress tolerance. Findings indicate that substance use, self-esteem, and distress tolerance should be targeted in high-risk MSM with CSA even if they do not have PTSD.
Access status: Open Access ,
Development and psychometric evaluation of the Brief Adolescent Gambling Screen (BAGS)
(Frontiers Media SA, 2017-12-19) Stinchfield, Randy; Wynne, Harold; Wiebe, Jamie; Tremblay, Joel
The purpose of this study was to develop and evaluate the initial reliability, validity and classification accuracy of a new brief screen for adolescent problem gambling. The three-item Brief Adolescent Gambling Screen (BAGS) was derived from the nine-item Gambling Problem Severity Subscale (GPSS) of the Canadian Adolescent Gambling Inventory (CAGI) using a secondary analysis of existing CAGI data. The sample of 105 adolescents included 49 females and 56 males from Canada who completed the CAGI, a self-administered measure of DSM-IV diagnostic criteria for Pathological Gambling, and a clinician-administered diagnostic interview including the DSM-IV diagnostic criteria for Pathological Gambling (both of which were adapted to yield DSM-5 Gambling Disorder diagnosis). A stepwise multivariate discriminant function analysis selected three GPSS items as the best predictors of a diagnosis of Gambling Disorder. The BAGS demonstrated satisfactory estimates of reliability, validity and classification accuracy and was equivalent to the nine-item GPSS of the CAGI and the BAGS was more accurate than the SOGS-RA. The BAGS estimates of classification accuracy include hit rate = 0.95, sensitivity = 0.88, specificity = 0.98, false positive rate = 0.02, and false negative rate = 0.12. Since these classification estimates are preliminary, derived from a relatively small sample size, and based upon the same sample from which the items were selected, it will be important to cross-validate the BAGS with larger and more diverse samples. The BAGS should be evaluated for use as a screening tool in both clinical and school settings as well as epidemiological surveys.
Access status: Open Access ,
Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9
(Public Library of Science (PLoS), 2017-07-01) Romagnuolo, Rocco; Scipione, Corey A.; Marcovina, Santica M.; Gemin, Matthew; Seidah, Nabil G.; Boffa, Michael B.; Koschinsky, Marlys L.
Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for cardiovascular disease. The mechanisms underlying Lp(a) clearance from plasma remain unclear, which is an obvious barrier to the development of therapies to specifically lower levels of this lipoprotein. Recently, it has been documented that monoclonal antibody inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) can lower plasma Lp(a) levels by 30%. Since PCSK9 acts primarily through the low density lipoprotein receptor (LDLR), this result is in conflict with the prevailing view that the LDLR does not participate in Lp(a) clearance. To support our recent findings in HepG2 cells that the LDLR can act as a bona fide receptor for Lp(a) whose effects are sensitive to PCSK9, we undertook a series of Lp(a) internalization experiments using different hepatic cells, with different variants of PCSK9, and with different members of the LDLR family. We found that PCSK9 decreased Lp(a) and/or apo(a) internalization by Huh7 human hepatoma cells and by primary mouse and human hepatocytes. Overexpression of human LDLR appeared to enhance apo(a)/Lp(a) internalization in both types of primary cells. Importantly, internalization of Lp(a) by LDLR-deficient mouse hepatocytes was not affected by PCSK9, but the effect of PCSK9 was restored upon overexpression of human LDLR. In HepG2 cells, Lp(a) internalization was decreased by gain-of-function mutants of PCSK9 more than by wild-type PCSK9, and a loss-of function variant had a reduced ability to influence Lp(a) internalization. Apo(a) internalization by HepG2 cells was not affected by apo(a) isoform size. Finally, we showed that very low density lipoprotein receptor (VLDLR), LDR-related protein (LRP)-8, and LRP-1 do not play a role in Lp(a) internalization or the effect of PCSK9 on Lp(a) internalization. Our findings are consistent with the idea that PCSK9 inhibits Lp(a) clearance through the LDLR, but do not exclude other effects of PCSK9 such as on Lp(a) biosynthesis.