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Dentofacial Injuries Associated with E-Scooter Use: A Narrative Review of the International Literature with Descriptive Data from a Prospective Multicenter Italian Clinical Series
IntroductionAs electric scooters become central to micro-mobility networks, emergency departments report a parallel surge in associated craniofacial...
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Real-World Data on the Effectiveness and Use of Intravenous Fosfomycin for the Treatment of Difficult-to-Treat Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria—A Subgroup Analysis from the FORTRESS Study
IntroductionThis subgroup analysis of the FORTRESS study aimed to evaluate clinical and microbiological outcomes, treatment patterns, and safety of...
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Association of long-term exposure to air pollution, built environment and air temperature with the incidence of prediabetes phenotypes, and prediabetes remission and progression to type 2 diabetes: a longitudinal study in the KORA cohort
Aims/hypothesisEnvironmental exposures have been adversely associated with the risk of diabetes but their role in the remission and progression of...
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Effectiveness and safety of enfortumab vedotin and pembrolizumab in a real-world patient population with urothelial carcinoma: results from a multi-institutional cohort (GUARDIANS)
IntroductionEnfortumab vedotin plus pembrolizumab (EVP) is the standard first-line treatment for metastatic or locally advanced urothelial carcinoma...
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Translation, cross-cultural adaptation and preliminary psychometric evaluation of the Victoria Respiratory Congestion Scale into Spanish
BackgroundDeath rattles are a frequent clinical sign in patients in an end-of-life situation, despite the lack of consensus on how to address them....
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Real-World Data on the Use of Intravenous Fosfomycin for the Treatment of Central Nervous System Infections: a Subgroup Analysis from the FORTRESS Study
IntroductionCentral nervous system (CNS) infections are associated with high morbidity and mortality, and their management is challenged by...
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Obesity rise plateaus in developed nations and accelerates in developing nations
Global reporting of obesity is commonly based on comparisons over multiple decades
1 and lacks a granular and systematic analysis of its dynamics. We...
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The effect of delays in cancer surgery due to the COVID-19 pandemic on cancer resectability and postoperative mortality in different tumor entities
BackgroundDuring the COVID-19 pandemic, prioritization of COVID-19 patients led to delays in oncological surgery, potentially impacting patient...
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Investigating the analytical robustness of the social and behavioural sciences
The same dataset can be analysed in different justifiable ways to answer the same research question, potentially challenging the robustness of...
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Catabolism of extracellular glutathione supplies cysteine to support tumours
Restricting amino acids from tumours is an emerging therapeutic strategy with substantial promise
1 . Although typically considered an intracellular...
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Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties
SARS-CoV-2 RNA contains guanine-rich sequences that form secondary structures known as G quadruplexes (G4s). The SARS-CoV-2 nonstructural protein...
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Navigating ethical challenges in the FORTEe randomised controlled trial: a multi-centre staff survey on exercise intervention for children and adolescents undergoing cancer treatment
BackgroundThe FORTEe randomised controlled trial (NCT05289739) investigates an exercise intervention for children and adolescents undergoing cancer...
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A benchmark of expert-level academic questions to assess AI capabilities
Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping...
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Astrometric Follow-up of Near-Earth Asteroid 2024 YR4 During a Torino Scale Level 3 Alert
The discovery of 2024 YR4presented the planetary defense community with the most significant impact threat in almost two decades, reaching level 3...
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Codes & Guidelines Comparison for the Design of Concrete Beams Reinforced with GFRP
The use of Glass-Fibre Reinforced Polymers (GFRP) to reinforce concrete elements has been widely accepted as an adequate strategy to provide more...
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The Role of Digital Twins in Building Climate Change Resilience
Climate change is one of the most important challenges for society to solve. However, it cannot be fixed solely through greenhouse gas reductions; it...
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Polygenic and developmental profiles of autism differ by age at diagnosis
Although autism has historically been conceptualized as a condition that emerges in early childhood
1 ,2 , many autistic people are diagnosed later in...
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Consensus on acromegaly therapeutic outcomes: an update
The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of...
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Oncogenic YAP sensitizes cells to CHK1 inhibition via CDK4/6 driven G1 acceleration
Replication stress is a driver of genomic instability, contributing to carcinogenesis by causing DNA damage and mutations. While YAP, the downstream...
