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Science 30 August 1991:
Vol. 253. no. 5023, pp. 1034 - 1037
DOI: 10.1126/science.1887219
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Articles

Science, Vol 253, Issue 5023, 1034-1037
Copyright © 1991 by American Association for the Advancement of Science

articles

A difference in hypothalamic structure between heterosexual and homosexual men

S LeVay

Salk Institute for Biological Studies, San Diego, CA 92186.

The anterior hypothalamus of the brain participates in the regulation of male-typical sexual behavior. The volumes of four cell groups in this region [interstitial nuclei of the anterior hypothalamus (INAH) 1, 2, 3, and 4] were measured in postmortem tissue from three subject groups: women, men who were presumed to be heterosexual, and homosexual men. No differences were found between the groups in the volumes of INAH 1, 2, or 4. As has been reported previously, INAH 3 was more than twice as large in the heterosexual men as in the women. It was also, however, more than twice as large in the heterosexual men as in the homosexual men. This finding indicates that INAH is dimorphic with sexual orientation, at least in men, and suggests that sexual orientation has a biological substrate.


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