The helicopter is self-deployable worldwide, with a ferry range over 2,100nm. Normal operating range is up to 1,100nm.

The tilt-rotor aircraft is available in three configurations: the Combat Assault and Assault Support MV-22 for the USMC and the US Army; the long-range special operations CV-22 for US Special Operations Command (US SOCOM); and the US Navy HV-22, for combat search and rescue, special warfare and fleet logistic support.

The first of four LRIP (low-rate initial production) MV-22 models completed operation and evaluation in August 2000. Following a crash in December 2000, a number of upgrades have been implemented including redesign of hydraulics and wiring in the nacelles and improved flight control software.

A two-year flight test programme began in May 2002 and a second OP/EVAL phase began in March 2005. USAF CV-22 resumed flight testing in September 2002. The first CV-22 was delivered to the USAF in October 2005.