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News and Updates

Woman uses gas analysis mass spectrometer at NBS for chemical analysis of gas or vapor mixtures

NIST Adds New 'Fingerprints' to Chemical Identification Database

June 17, 2020

The National Institute of Standards and Technology (NIST) has updated its database of chemical fingerprints, called mass spectra, that are used to identify

A Solution to a Hairy Problem in Forensic Science

November 5, 2019

In an effort to make hair comparison a more useful technique for investigating crimes, scientists at the National Institute of Standards and Technology (NIST)

How the Cone Snail’s Deadly Venom Can Help Us Build Better Medicines

October 10, 2017

Cone snails have inspired humans for centuries. Coastal communities have often traded their beautiful shells like money and put them in jewelry. Many artists

Projects and Programs

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

A new collaboration between NIST's Human Genomics Team, Mass Spectrometry Data Center, and Information Technology Laboratory to use and develop artificial

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Human Gut Microbiome Reference Material

Ongoing

To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need

NIST Urine Albumin Standardization Program

Ongoing

The NIST Urine Albumin Standardization Program is focused on the development of a measurement procedure and reference materials to support an international

Publications

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

Liver proteome response to torpor in a basoendothermic mammal, Tenrec ecaudatus, provides insights into the evolution of homeothermy

October 6, 2021

Author(s)

Jane Khudyakov, Michael Treat, Mikayla Shanafelt, Jared Deyarmin, Ben Neely, Frank van Breukelen

Many mammals use adaptive heterothermy (e.g., torpor, hibernation) to reduce metabolic demands of maintaining high body temperature (Tb). Torpor is typically

Quantitative proteomic analysis for evaluating affinity isolation of extracellular vesicles

September 28, 2021

Author(s)

Ai Nguyen, Tingting Wang, Illarion Turko

Absolute quantification with mass spectrometry and isotope labelled internal standards has found broad applications in biomedical research. In the present

Rewinding the Molecular Clock: Looking at Pioneering Molecular Phylogenetics Experiments in the Light of Proteomics

September 15, 2021

Author(s)

Ben Neely, Magnus Palmblad

Science is full of overlooked and undervalued research waiting to be rediscovered. Proteomics is no exception. In this perspective, we follow the ripples from a

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