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News and Updates

Sneezes, Rain Clouds and Ink Jets: NIST Improves the Ability of Optical Microscopes to Measure the Volume of Microdroplets

December 20, 2021

Sneezes, rain clouds, and ink jet printers: They all produce or contain liquid droplets so tiny it would take several billion of them to fill a liter bottle

Neutrons Help Measure Cell Membrane Viscosity — and Reveal Its Basis

August 12, 2021

We now have a clearer picture of the lightning-fast molecular dance occurring within the membrane that encloses each cell in our body, revealed in part by

Identifying Individual Molecules: NIST Study Suggests How to Build a Better ‘Nanopore’ Biosensor

April 27, 2021

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such

Projects and Programs

Molecular Physiology

Ongoing

The natural world is a magnificent place with observable, via measurement and inference, physical structures spanning at least 43 orders of magnitude in space

Calibration Services: National Air-Kerma Standard for Electronic Brachytherapy

Ongoing

The Dosimetry Group calibrates well-type ionization chambers using Xoft miniature x-ray sources, which provide low-energy x-rays (< 50 keV) for electronic

Nano-biophotonics for molecular imaging

Ongoing

Biophotonics is at the intersection of photonics and biology where light is used to image, detect, and manipulate biological materials. This project addresses

Protocol for Preparing Fibrillar Collagen Matrices on Untreated Polystyrene Labware (Petri)*: A Potential Reference Extracellular Matrix With Robust and Reproducible Cell Responses

Ongoing

Background: Collagen type 1 is the most prevalent extracellular protein in connective tissue, and is part of the family of collagens that are fibril forming

Publications

Micromechanical Compatibility Between Cells and Scaffolds Directs Phenotypic Transition of Stem Cells

January 28, 2022

Author(s)

Yang Song, Jiaoyue Long, Jeremiah Woodcock, Joy Dunkers, Hung Chun Lin, Douglas M. Fox, Xiaoling Liao, Yonggang Lv, Li Yang, Martin Chiang

This study experimentally substantiates the micromechanical compatibility between cell and substrate is essential for cells to achieve energetically favorable

Measuring Excess Heat Capabilities of Deoxyribonucleic Acid (DNA) Folding at the Single-Molecule LEvel

January 3, 2022

Author(s)

David Nicholson, Bin Jia, David Nesbitt

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

Modulation of a protein-folding landscape revealed by AFM-based force spectroscopy notwithstanding instrumental limitations

December 7, 2021

Author(s)

Devin T. Edwards, Marc-Andre LeBlanc, Thomas Perkins

Software

NIST's Integrated Colony Enumerator (NICE)

January 4, 2021

Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size

Tools and Instruments

Beamline 10: Quantitative Hyperspectral Infrared Microscopy

The new beamline 10, currently under construction, is intended for applications that make use of the super-thermal brightness from SURF in the near- to mid

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Biological physics

News and Updates

Projects and Programs

Publications

Software

Tools and Instruments