A multidimensional array in Python is an array that contains more than one array as its elements, creating a matrix-like structure. Python supports multidimensional arrays through lists or with the help of the NumPy library for more advanced operations. Commonly used for tasks involving grids, tables, or other complex data structures, they can be created using nested lists or NumPy's array function. NumPy arrays provide efficient and easy manipulation of multidimensional data. Accessing elements involves using multiple indices, like array[row][column], for 2D arrays.