British Journal of Hospital Medicine (BJHM) is published by IMR Press from Volume 87 Issue 1 (2026). Previous articles were published by another publisher under the hybrid model (CC-BY-NC license or on a subscription basis), and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Memantine (Ebixa®) in the later stages of dementia
David J Findlay 1, Peter J Connelly 2
Affiliations
Article Info
1 Department of Old Age Psychiatry, Royal Dundee Liff Hospital, Dundee DD2 5NF and
2 Department of Old Age Psychiatry at Murray Royal Hospital, Perth
Abstract
Memantine is the first agent licensed for the treatment of moderate to severe Alzheimer's disease. It is an N-methyl D-aspartate (NMDA) receptor antagonist which reduces glutamatergic excitotoxicity. Benefits are seen in cognitive, functional and global measures in both outpatients and nursing home residents. Prospective health economic benefits have been reported.