This Collection showcases recent advances in cell and gene therapies aimed at treating diseases resistant to conventional approaches, including cancers, autoimmune disorders, and etc.

CRISPR-Cas9 technology has revolutionized biotechnology by providing an efficient, precise, and versatile tool for genome editing.

This Collection welcomes contributions on key metabolic pathways, emerging biomarkers, novel therapeutic targets, and the role of metabolic reprogramming on tumor progression and therapy resistance.

This Collection focuses on innovative therapeutic strategies based on the mechanisms of disease pathogenesis and brain function abnormalities in refractory brain disorders.