Sayers et al. reveal that heart regeneration during the neonatal period in mice extends to conduction system restoration after insult, highlighting the difference between this process and pathological remodeling in the adult heart.

Maatz, Lindberg et al. identify molecular alterations and immune response changes in endomyocardial biopsies from patients with myocarditis after COVID-19 infection, after anti-COVID-19 vaccination or from non-COVID-related causes.

Using single-cell and spatial molecular profiling of infarcted mouse and human hearts, Li, Ni, Wang and colleagues identify a subset of cardiac fibroblasts expressing CD248 that plays a critical role in fibroblast–T cell interaction, and show that disrupting this interaction with monoclonal antibodies or anti-CD248 chimeric antigen receptor T cells results in reduced cardiac fibrosis and improved function.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Barrios et al. develop a multiview deep neural network to jointly analyze multiple echocardiographic video views, improving detection of cardiac anatomy and function.

Smyth et al. demonstrate that a cellular inhibitor of apoptosis, cIAP2, exacerbates inflammation and cardiac injury after myocardial infarction and that its inhibition, either genetically or via Smac mimetics, offers a promising immunotherapeutic strategy to reduce post-MI damage and progression to heart failure.

Li, Turaga and colleagues reveal intrinsic cardiomyocyte senescence and a hypoxic, mechanically stressed microvascular niche in hypoplastic left heart syndrome right ventricles and demonstrate that ventricular assist device therapy can alleviate these senescent states.

Kayman Kürekçi et al. show that fibulin-2 regulates epicardial cell activation through nuclear protein 1b signaling to balance fibrosis and regeneration after cardiac injury, and modulating this pathway can enhance heart regeneration in zebrafish.

Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models.